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[2].GB/Z 16886.22-2022;SuhVhuirf[ċN,{22R~s|PgecWS[S]. [3].GB/T 16886.1-2022;SuhVhuirf[ċN,{1RΘi{tǏ z-NvċNNՋ[S]. [4].'k2mfNel-N_EURL ECVAM . Validated test methods - health effects[EB]https://joint-research-centre.ec.europa.eu/eu-reference-laboratory-alternatives-animal-testing-eurl-ecvam/alternative-methods-toxicity-testing/validated-test-methods-health-effects_en, 2023.09.12. [5].GB/T 16886.12-2017;SuhVhuirf[ċN,{12R7hT6RYNSgqPge[S]. [6].GB/T 16886.5-2017;SuhVhuirf[ċN,{5RSOY~ހk'`Ջ[S] [7].YY/T 0993-2015;SuhVhuirf[ċN~s|PgeSOY~ހk'`Ջ(MTTՋTLDHՋ)[S]. [8].ASTM E2526-082013 Standard Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials in Porcine Kidney Cells and Human Hepatocarcinoma Cells[S]. [9].GB/T 16886.3-2019;SuhVhuirf[ċN,{3RW Ok'`0Lv'`Tukk'`Ջ[S]. [10].YY/T 0870.3-2019 ;SuhVhW Ok'`Ջ,{3R:(u\ m]$v~ހۏLvTKWVzSՋ[S]. [11].OECD 476 In vitro Mammalian Cell Gene Mutation Test[S]. [12].YY/T 0870.6-2019 ;SuhVhW Ok'`Ջ,{6R:SOYTsNRir~ހ_8hՋ[S]. [13].YY/T 0870.2-2019 ;SuhVhW Ok'`Ջ,{2R:SOYTsNRir~ހgrSOxuSՋ[S]. [14].YY/T 0870.4-2014;SuhVhW Ok'`Ջ,{4RTsNRirӚ~~ހ_8hՋ[S]. [15].YY/T 0870.5-2014 ;SuhVhW Ok'`Ջ,{5RTsNRirӚgrSOxuSՋ[S]. [16].OECD 489 In vivo Mammalian Alkaline Comet Assay[S]. [17].OECD 483 Mammalian Spermatogonial Chromosomal Aberration Test[S]. [18].OECD 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays[S]. [19].GB/T 16886.11-2021;SuhVhuirf[ċN,{11RhQk'`Ջ[S]. [20].GB/T 21804-2008 Sf[T%`'`~Sk'`V[BRϑՋel[S]. [21].GB/T 21757-2008 Sf[T%`'`~Sk'`Ջ%`'`k'`R{|l[S]. [22].GB/T 21826-2008 Sf[T%`'`~Sk'`Ջel N NXQBRϑl[S]. [23].GB/T 21605-2008 Sf[T%`'`8TeQk'`Ջel[S]. [24].GB/T 28648-2012 Sf[T%`'`8TeQk'`Ջ%`'`k'`R{|l[S]. [25].GB/T 21606-2022 Sf[T%`'`~vk'`Ջel[S]. [26].GB .0JL^`6 D zʺtccRA!h2~h1B*CJ PJaJ ph!h2~hy]B*CJ PJaJ ph h2~hM0B*CJ \aJ ph!h2~ha=B*CJ PJaJ ph!h2~hM0B*CJ PJaJ ph'h2~hM0B*CJ,PJ\aJ,o(phh2~B*CJ,PJ\aJ,phhM0B*CJ,PJ\aJ,ph$h2~h2~B*CJ PJ\aJ phhM0B*CJ PJ\aJ ph$h2~hM0B*CJ PJ\aJ ph 0L` 6 D 8 R H$.$$dWDXD` dWD`$dUD]a$gd2~ dUD]gd2~. ( f !"$%%%8kd$$If*!!!644 la $d$Ifa$ & F dWD^` dWD`z|%%%).):)d**33333N;R;@@@CCvFxFR`ݻ݋~m\~KDBU h2~hM0 h2~hM0B*CJ \aJ ph!h2~h#IB*CJ PJaJ ph!h2~h(ZDB*CJ PJaJ phh2~hM0CJ PJaJ !h2~hTB*CJ PJaJ ph!h2~hM0B*CJ PJaJ phh2~hM0CJ PJ\aJ h2~hM0B*CJPJph%jh2~hM0UmHnHsHtH!h2~hM0B*CJ PJaJ ph!h2~h B*CJ PJaJ ph% &&*(().):)**,,..:1\1223334<6L678 dWD` $dWD`a$ $dWD`a$88::D;4<<t==>?@@ACCvEE@FZHHIIJJK $dWD`a$$$dWDXD` dWD`JKK>LLMMMfNNOOJPPPLQQQJ``fabbbRccdddle $dWD`a$/T 21604-2008 Sf[T%`'`v:Ro'`/P'`Ջel[S]. [27].GB/T 16886.10-2017;SuhVhuirf[ċN,{10R:RoNvOeՋ[S]. [28].OECD 430 In vitro Skin Corrosion Transcutaneous Electrical Resistance Test (TER)[S]. [29].OECD 431 In vitro Skin Corrosion: Reconstructed Human Epidermis (RhE) Test Method[S]. [30].GB/T 16886.4-2022;SuhVhuirf[ċN,{4RN@mvN\O(uՋ b[S]. [31].YY/T 1532-2017 ;SuhVhuirf[ċN~s|Pgen@Ջ[S]. [32].GB/T 16886.16-2021;SuhVhuirf[ċN,{16RM㉧NirNSlnirkNRRf[xvz[S]. [33].YY/T 1295-2015 ;SuhVhuirf[ċN~s|Pge~̃Qk }Ջ[S]. [34].GB/T 16886.6-2022;SuhVhuirf[ċN,{6R ieQT@\S^Ջ[S]. [35].OECD 421 Reproductive toxicity screening test[S]. [36].OECD 414 Prenatal Developmental Toxicity Test[S]. [37].OECD 415 One Generation Reproduction Toxicity Study[S]. [38].OECD 416 Two Generation Reproduction Toxicity Study[S]. [39].OECD 422 Combined Repeated Dose Toxicity Study[S]. [40].EFSA. Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health: 29 May 2018[Z]. [41]. V[oTvcw{t@\oT[ċ-N_.~s|oir^4N^[hQ'`xvzb/gc[SRՋL : V[ov@\o[-N_2021t^,{35SJT[Z]. [42]. V[oTvcw{t@\oT[ċ-N_.oirW Ok'`xvzb/gc[SR: 2018t^3g15e[Z]. [43].ISO/TR 22019:2019 Nanotechnologies  Considerations for performing toxicokinetic studies with nanomaterials[S]. [44].ICH S1B oirLv'`Ջ[S]. [45].ICH S5(R3) N(uoirukNSk'`hKm[S]. 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